Dr. Andres is interested in understanding the molecular mechanisms of bacterial DNA damage response and repair and the role these interactions play in driving the evolution of antimicrobial resistance.
Dr. Bhatia is interested in human somatic and pluripotent stem cell development on a molecular level. More specifically, he focuses on characterization of pathways that govern such cells, including self-renewal and differentiation mechanisms, while employing novel in vivo models for cell and tissue regeneration.
The Bowdish lab studies the process of macrophage phagocytosis, how macrophages influence the composition of the microbiome of the upper respiratory tract and how they recognize and destroy Streptococcus pneumoniae, the major cause of pneumonia in the elderly.
Dr. Brown works on bacterial molecular genetics, with a special interest in a biochemical approach to understanding and combatting antibiotic resistance, in addition to bacterial cell structure biogenesis.
Dr. Coombes works on understanding the relationship between pathogenic bacteria and their hosts, and how this relationship changes biologically and physiologically with respect to pathology and immunology. His lab in particular has a special interest in GI tract diseases.
Dr. Li studies the various applications of single-stranded DNA and RNA (ssDNA, ssRNA) including catalytic and binding functions. Additionally, the Li Lab creates novel ssDNA/ssRNA molecules with the intention of screening for novel functions.
As a new member to SCC-RI, Dr. Lu utilizes proteomics and systems biology to study alternative splicing regulatory mechanisms to profile splicing isoforms, characterize splicing factors, and pinpoint signaling pathways of differentiation of pluripotent human embryonic stem cells and iPSC.
The MacNeil lab studies the impacts of diet and microbiota on larger-scale factors, including health and development and disease susceptibility and progress. The MacNeil lab uses high-throughput screening to identify key genes that modify an organism's response to specific environmental factors, and often uses the nematode C. elegans as a model organism.
Dr. McArthur and the McArthur lab's work spans bioinformatic approaches to sequencing and analyzing genomic causes of bacterial drug resistance, in addition to the creation of novel biological databases and the ongoing development of the Comprehensive Antibiotic Resistance Database (CARD).
Dr. Miller and his lab study innate and adaptive immune responses elicited in humans. Specifically, one area of research involves regulators of the primary immune response in the context of amyotrophic lateral sclerosis (ALS) and inflammation. Responses to influenza A viruses are also of large interest, with the goal of furthering the development of a “universal” broadly cross-protective vaccine.
Dr. Singh and his lab study the pathological mechanisms involved in schizophrenia and autism spectrum disorders by employing "in utero electroporation" to identify disruptive gene function in developmental brain events and determine functionality of disease-associated risk genes on neural stem cell proliferation/differentiation and neuronal synapses.
Dr. Truant and his lab have developed novel tools that assist in viewing protein transport through the body's organelles, employing this research to genetically inherited neurodegenerative diseases, such as Huntington's disease.
Research in the Whitney lab employs a multidisciplinary approach to uncover the molecular details of pathways that shape the composition of bacterial communities. Specific areas of research include interbacterial competition and bacterial adhesion.
In response to the acquired antibiotic resistance era society currently resides in, Dr. Wright's lab investigates the molecular mechanisms of bacterial resistance and antibiotic biosynthesis with aspirations to create novel antibiotics.
The Ask lab focuses on the biological mechanisms of fibrosis or scarring, with particular emphasis on chronic lung disease and inflammatory conditions. Focusing on the role of macrophages and the unfolded protein response in the pathogenesis of lung diseases, the Ask Lab employs a cross-disciplinary approach to research. Through partnerships with clinicians, molecular pathologists, and biomedical researchers, the lab aims to better understand chronic lung diseases and how they can be pharmacologically prevented.
Utilizing the bacterium Streptomyces coelicolor as their model system, the Elliot lab studies cellular dormancy and resuscitation, particularly focusing on cellular differentiation in a multicellular bacterium with ambition to determine novel RNA regulatory networks and integrate it into known regulation events that control development and antibiotic production and stimulate antibiotic production to identify new antibiotics to combat against disease.
As an Associate member in both Kinesiology and Biochemistry and Biomedical Sciences, Dr. Hawke employs molecular, cellular, and physiological approaches in studying muscle satellite cells in diseases, including diabetes mellitus and limb girdle muscular dystrophy.